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Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

Wenjun Xia,Fei Liu,Duan Ma

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 137-142 doi: 10.1007/s11684-016-0449-8

Abstract: high-, mid-, low-, and total-frequency hearing loss.An audiometric finding of mid-frequency sensorineural hearing loss, or a “bowl-shaped” audiogramUp to now, merely 7 loci have been linked to mid-frequency hearing loss.Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA)This review summarizes the research progress of the four genes to draw attention to mid-frequency deafness

Keywords： hereditary non-syndromic hearing loss     mid-frequency hearing loss     deafness genes    

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Ionically Imprinting-Based Copper (Ⅱ) Label-Free Detection for Preventing Hearing Loss Article

Huan Wang, Hui Zhang, Xiaoli Zhang, Hong Chen, Ling Lu, Renjie Chai

Engineering doi: 10.1016/j.eng.2023.09.001

Abstract: ion (Cu2+) may cause severe health problems, such as hair cell apoptosis and the resultant hearingloss.IIHBs are promising candidates for Cu2+ detection, particularly for the prevention of hearingloss.

Keywords： Structural color     Microfluidics Ionic imprinting     Label-free detection     Hearing loss    

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Frontiers of Medicine doi: 10.1007/s11684-023-1006-x

Abstract: Notably, the biallelic loss-of-function variants of TMEM141 were responsible for syndromic ID.

Keywords： neurodevelopmental disorder     autosomal recessive intellectual disability     consanguinity     spastic paraplegia     hearingloss     TMEM141    

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Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 250-257 doi: 10.1007/s11684-016-0454-y

Abstract: Alternative splicing along the tonotopic axis of the cochlea contributes to frequency tuning, particularlychannel (BK channel), has been suggested to affect the channel gating properties and is important for frequencyConsequently, deficits in alternative splicing have been shown to cause hearing loss, as we can observeFurther investigation is also needed to clarify the mechanism of hearing loss caused by alternative splicing

Keywords： alternative splicing     inner ear     hearing loss     hair cells    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinase. LKB1 plays crucial roles in cell differentiation, proliferation, and polarity. In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated using Pax2-Cre mice to investigate the function of LKB1 in inner ear hair cells during early embryonic period. LKB1Pax2 CKO mice died perinatally. Immunofluorescence and scanning electron microscopy revealed that stereociliary bundles in LKB1Pax2 CKO mice were clustered and misoriented, respectively. Moreover, ectopic distribution of kinocilium bundles resulting from abnormal migration of kinocilium was observed in the mutant mice. The orientation of stereociliary bundles and the migration of kinocilia are critical indicators of planar cell polarity (PCP) of hair cells. LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during embryonic development. Our results suggest that LKB1 is required in PCP formation in cochlear hair cells in mice.

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Research of mid and high frequency response of complex mechanical structures using energy finite element

Zhu Danhui,Xie Miaoxia,Kong Xiangjie,Zhang Wenbo,Chen Hualing

Strategic Study of CAE 2013, Volume 15, Issue 1,   Pages 106-112

Abstract: conical shell, and this method help us to obtain the local detail response of complex structures in midand high frequency range; the second part is that we extend the EFEM to predict the vibro-acoustical

Keywords： mid and high frequency response     energy finite element method     prediction of vibro-acoustical response    

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Alternate partial root-zone irrigation with high irrigation frequency improves root growth and reducesunproductive water loss by apple trees in arid north-west China

Shaoqing DU, Ling TONG, Shaozhong KANG, Fusheng LI, Taisheng DU, Sien LI, Risheng DING

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 188-196 doi: 10.15302/J-FASE-2017176

Abstract: The results show that in comparison with conventional irrigation, APRI with high frequency significantlyOverall, alternate partial root-zone irrigation with high frequency has a great potential to promoteroot growth, expand water uptake capacity and reduce unproductive water loss in the arid apple production

Keywords： alternate partial root-zone irrigation     apple tree     leaf water use efficiency     root length density     stomatal conductance     water potential    

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Experimental study on seismic behavior of mid-rise RC shear wall with concealed truss

Wanlin CAO, Jianwei ZHANG, Jingna ZHANG, Min WANG,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 370-377 doi: 10.1007/s11709-009-0062-x

Abstract: In this paper, mid-rise shear wall with concealed truss was proposed.The experimental study on the seismic behavior of six 1/3 scale mid-rise shear walls, including an ordinarymid-rise shear wall, a mid-rise shear wall with steel frame, and four mid-rise shear wall with concealedThe experimental results show that the seismic behavior of the mid-rise shear wall with steel frame and

Keywords： reinforced concrete     profile steel     concealed truss     mid-rise shear wall     seismic behavior    

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Review of recent advances of polymer based dielectrics for high-energy storage in electronic power devices from the perspective of target applications

Wenjie Sun, Jiale Mao, Shuang Wang, Lei Zhang, Yonghong Cheng

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 18-34 doi: 10.1007/s11705-020-1939-4

Abstract: Low electric loss is a critical prerequisite for capacitors for electric grids, while high-temperature

Keywords： dielectric capacitors     polymer-based dielectrics     energy density     dielectric loss     working temperature     frequency    

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A survey of decorative materials on the energy consumption of mid-rise residential buildings in Mashad

Masoud Taheri SHAHRAEIN, Lihua ZHAO, Qinglin MENG

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 4,   Pages 490-497 doi: 10.1007/s11709-010-0068-4

Abstract: Polyvinylchloride (PVC) panel is one of the most favorite decorative materials that has been popularly applied as finishing of ceiling in residential buildings. It is about five years that the people incline to redecorate the ceiling of old buildings with PVC panel in big cities of Iran, such as Mashad. In this study, the influence of ceiling PVC panel on the cooling and heating loads of studied apartment were determined by software DeST-h. In addition, the summer natural ventilation of the mentioned apartment is investigated by determining the wind speed into the apartment through the computational fluid dynamics (CFD) software. The evaluation of environment indoor wind velocity showed that most of the apartment space is a comfortable zone. The results of studied building analyses demonstrated that using PVC panel on the ceiling can decline the energy consumption of the penthouse (fifth level) of the investigated building, which is about 3.7% and 7% for studied methods of without and with air layer, respectively. In addition, although the existence of air layer can decline the cooling and heating loads, the increase in air layer thickness did not show significant decrease on building energy consumption. However, the PVC panel is expensive and is not suitable to be used for ceiling thermal insulation, but adding a thin layer of air between ceiling and PVC panel can be a good step toward sustainable building, when the people are inclined to utilize it as a decorative ceiling.

Keywords： residential apartments     natural ventilation     energy consumption     decorative materials     Mashad    

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Synthesis of mid-dicarboxy polystyrene by ATRP and formation of ionic-bonded supramolecules

YU Tao, WANG Yun, LU Dairen, BAI Ruke, LU Weiqi

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 2,   Pages 140-145 doi: 10.1007/s11705-007-0026-4

Abstract: A well-defined novel structural polystyrene containing two ester groups in the mid-main chain was prepared

Keywords： controlled molecular     conversion     bromination     relationship     isophthalate    

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Power fluctuation and power loss of wind turbines due to wind shear and tower shadow

Binrong WEN, Sha WEI, Kexiang WEI, Wenxian YANG, Zhike PENG, Fulei CHU

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 3,   Pages 321-332 doi: 10.1007/s11465-017-0434-1

Abstract: the effects of wind shear and tower shadow on power output in terms of power fluctuation and power lossPower fluctuation and power loss due to wind shear and tower shadow are analyzed by performing theoreticalUnder steady wind conditions, power loss can be divided into wind farm loss and rotor loss.Wind farm loss is constant at 3α(3α−1)R2/(8By contrast, rotor loss is strongly influenced by the wind turbine control strategies and wind speed.

Keywords： wind turbine     wind shear     tower shadow     power fluctuation     power loss    

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Turnover and loss of nitrogenous compounds during composting of food wastes

YANG Yanmei, ZHANG Xiangfeng, YANG Zhifeng, XI Beidou, LIU Hongliang

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 2,   Pages 251-256 doi: 10.1007/s11783-008-0042-8

Abstract: This study aimed to investigate the solid-phase nitrogen, water-soluble nitrogen, nitrogen loss togethercontent of the water-soluble nitrogen compounds in the compost greatly increased, the total nitrogen losssuggested that the control at the middle and late composting of thermophilic stage is the key to nitrogen loss
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Study of mid-long term power supply capacity in China

Bai Jianhua,Xin Songxu

Strategic Study of CAE 2011, Volume 13, Issue 6,   Pages 65-74

Abstract: in China and relevant energy development policies, this paper comprehensively analyzed China's mid-longBased on this, with the objective of minimizing the total cost to society, it also optimized the mid-longterm generation mix in China, and proposed the mid-long term generation arrangement.

Keywords： power supply capacity     mid-long term     generation mixture     generation arrangement    

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Winner determination problem with loss-averse buyers in reverse auctions

Xiaohu QIAN, Min HUANG, Yangyang YU, Xingwei WANG

Frontiers of Engineering Management 2017, Volume 4, Issue 2,   Pages 212-220 doi: 10.15302/J-FEM-2017019

Abstract: novel winner determination problem in a multiple-object reverse auction in which the buyer involves loss-averseIn addition, the proposed model can effectively characterize the buyer’s loss-averse behavior.

Keywords： reverse auction     loss aversion     winner determination     improved ant colony algorithm    

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Title Author Date Type Operation

Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness

Wenjun Xia,Fei Liu,Duan Ma

Journal Article

Ionically Imprinting-Based Copper (Ⅱ) Label-Free Detection for Preventing Hearing Loss

Huan Wang, Hui Zhang, Xiaoli Zhang, Hong Chen, Ling Lu, Renjie Chai

Journal Article

Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Journal Article

Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Research of mid and high frequency response of complex mechanical structures using energy finite element

Zhu Danhui,Xie Miaoxia,Kong Xiangjie,Zhang Wenbo,Chen Hualing

Journal Article

Alternate partial root-zone irrigation with high irrigation frequency improves root growth and reducesunproductive water loss by apple trees in arid north-west China

Shaoqing DU, Ling TONG, Shaozhong KANG, Fusheng LI, Taisheng DU, Sien LI, Risheng DING

Journal Article

Experimental study on seismic behavior of mid-rise RC shear wall with concealed truss

Wanlin CAO, Jianwei ZHANG, Jingna ZHANG, Min WANG,

Journal Article

Review of recent advances of polymer based dielectrics for high-energy storage in electronic power devices from the perspective of target applications

Wenjie Sun, Jiale Mao, Shuang Wang, Lei Zhang, Yonghong Cheng

Journal Article

A survey of decorative materials on the energy consumption of mid-rise residential buildings in Mashad

Masoud Taheri SHAHRAEIN, Lihua ZHAO, Qinglin MENG

Journal Article

Synthesis of mid-dicarboxy polystyrene by ATRP and formation of ionic-bonded supramolecules

YU Tao, WANG Yun, LU Dairen, BAI Ruke, LU Weiqi

Journal Article

Power fluctuation and power loss of wind turbines due to wind shear and tower shadow

Binrong WEN, Sha WEI, Kexiang WEI, Wenxian YANG, Zhike PENG, Fulei CHU

Journal Article

Turnover and loss of nitrogenous compounds during composting of food wastes

YANG Yanmei, ZHANG Xiangfeng, YANG Zhifeng, XI Beidou, LIU Hongliang

Journal Article

Study of mid-long term power supply capacity in China

Bai Jianhua,Xin Songxu

Journal Article

Winner determination problem with loss-averse buyers in reverse auctions

Xiaohu QIAN, Min HUANG, Yangyang YU, Xingwei WANG

Journal Article